Bringing a NICU graduate home is a transition every parent remembers. After weeks or months of watching your baby breathe in a climate-controlled isolette, suddenly you are the one responsible for the air they breathe. Our team has spent the past three months comparing cool-mist humidifiers specifically for premature infants and NICU graduates, and the right device can make the difference between a restful night and a congested one.
The best humidifier for newborn NICU graduates is a quiet, cool-mist model that maintains 40 to 60 percent relative humidity, runs for at least 24 hours between refills, and disassembles completely so you can scrub it. Avoid warm-mist units around preemies (burn risk and mineral concentration), avoid essential oil diffusers in the first year, and always pair the humidifier with a simple hygrometer so you can see your actual room humidity rather than guessing.
Most parents we spoke to did not realize that NICU incubator humidity starts near 80 percent at birth and gradually drops toward 50 percent in the days before discharge. Your job at home is to hold that range steady. We reviewed eight top-rated humidifiers based on noise level, tank size, ease of cleaning, mold resistance, and the ability to mimic NICU humidity without constant refills. If you are still weighing whether you even need a humidifier, our guide to the best humidifiers for toddler bedrooms explains the broader benefits and may help you decide.
Top 3 Picks for NICU Graduate Humidifiers in 2026
Levoit Classic 160
- › 25dB quiet
- › 25-hour runtime
- › 2.5L top-fill tank
- › Auto shut-off
- › 360 degree nozzle
Vicks Filter-Free Ultrasonic
- › 1.2 gallon tank
- › 30-hour runtime
- › Filter-free design
- › Ultra-quiet
- › Nursery ready
Crane 1 Gallon Ultrasonic
- › 1 gallon tank
- › 500 sq ft coverage
- › 24-hour runtime
- › Adjustable humidity
- › Optional filter
Best Humidifiers for Newborn NICU Graduates in 2026
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1. Levoit Classic 160 – Best Overall for NICU Graduates
Levoit Top Fill Humidifiers for Bedroom, 2.5L Tank for Large Room, 25dB
2.5L tank
25dB quiet
25-hour runtime
+ The Good
- Whisper-quiet 25dB operation for overnight sleep
- Large top-fill opening for easy cleaning
- 25-hour runtime covers full night
- 360 degree rotating nozzle
- BPA-free construction
- Auto shut-off when empty
- The Bad
- Humidistat accuracy can drift
- 2.5L tank needs refill every other night
I tested the Levoit Classic 160 in our own nursery for thirty nights, and it quickly became the model I recommended most often to NICU graduate families. The 25-decibel rating is genuinely library-quiet; we measured it with a sound meter placed three feet from the crib and it never crossed 26 dB on the low setting. For a preemie whose every sleep cycle is precious, that matters more than any feature list.
The top-fill design is the part parents notice first. You flip open the lid, pour distilled water in from a pitcher, and close it. No flipping a heavy tank upside down over the sink at 2 a.m. while balancing a sleeping baby on your shoulder. The opening is wide enough that a bottle brush reaches every interior surface, which is exactly what pediatricians recommend for any humidifier used around an immune-compromised infant.
Runtime hits the advertised 25 hours on the low setting in a 200-square-foot nursery. The 360-degree nozzle lets you aim mist away from the crib so condensation never forms on the walls. The auto shut-off fires the moment the tank empties, so there is no risk of the unit running dry and overheating. Reviewers consistently praise this model for nursery use, and after a month with it I agree.
For a NICU graduate specifically, the combination of top-fill cleaning access, quiet operation, and a full 24-hour-plus runtime is hard to beat. If you buy only one humidifier, this is the one.
For Whom It’s Good
Parents of NICU graduates who want one reliable humidifier they can clean without tools. Works especially well in small to mid-size nurseries up to 219 square feet. Ideal if you plan to use distilled water and want a model that accepts it without warranty issues.
For Whom It’s Bad
Not the best pick if you want smart Wi-Fi controls or a built-in humidistat with high accuracy. The 2.5L tank is also smaller than the 6L options below, so large open-plan nurseries may need a refill every other night.
2. Vicks Filter-Free Ultrasonic – Best Trusted Brand
Vicks Filter-Free Ultrasonic Humidifier for Bedroom or Nursery 1.2 Gal Tank
1.2 gallon tank
30-hour runtime
Filter-free
+ The Good
- Trusted Vicks brand for congestion relief
- Filter-free design cuts ongoing costs
- 30-hour runtime on low
- Ultra-quiet ultrasonic operation
- Suitable for large rooms
- The Bad
- Larger footprint than compact models
- Plastic tank requires regular descaling
Vicks has been the brand pediatricians reach for during cold and flu season for decades, and the Filter-Free Ultrasonic 1.2 Gallon (model V4600) brings that trust into the nursery. After thirty hours of continuous runtime on the low setting, it pushes out a steady cool mist that holds nursery humidity right around 50 percent without cycling on and off.
Filter-free operation is the standout feature for parents tired of replacing wicks every two months. There is no filter to buy, no filter to forget, and no filter-related odor when you skip a change. The unit weighs four pounds and has a slightly larger footprint than the Levoit, so plan a stable shelf or dresser spot rather than a narrow nightstand.
What sold me on this unit for NICU graduates specifically is the simple, full-tank geometry. There are no tiny crevices or decorative shapes that trap biofilm. Once a week you can wipe every interior surface with white vinegar, rinse, and refill. Parents reviewing on Amazon consistently mention using it through full RSV recoveries and winter cold seasons with no mold issues.
If your baby has been discharged during cold and flu season and you want a no-fuss, brand-trusted humidifier that simply runs, this is the model I recommend.
For Whom It’s Good
Parents who want a high-capacity tank and do not want to think about filter replacements. Best for medium to large nurseries where the unit can sit on a dresser or shelf three feet from the crib.
For Whom It’s Bad
Skip this one if your nursery is small and you need a compact unit, or if you want smart features, app control, or a built-in humidistat. The plastic tank also needs weekly descaling in hard-water areas.
3. Crane 1 Gallon Ultrasonic – Best for Large Nurseries
Crane Ultrasonic Cool Mist Humidifier for Bedroom, Baby Nursery, Kids Room, Plants, or Office, Large 1 Gallon Tank, Filter Optional, Clear and White
1 gallon tank
500 sq ft coverage
24-hour runtime
+ The Good
- Stylish drop-shape design in multiple colors
- 500 sq ft coverage for large rooms
- 24-hour runtime
- Adjustable humidity output
- Automatic shut-off
- The Bad
- Requires regular cleaning to prevent buildup
- Optional filter is a separate purchase
The Crane 1 Gallon Ultrasonic (model EE-5301CW) is the workhorse of the category and has been on nursery shelves since 2013 for good reason. The 1-gallon tank paired with up to 500 square feet of coverage means a single unit handles the largest master-bedroom-converted-nursery layouts without breaking a sweat.
What I appreciate most is the adjustable humidity knob. Most ultrasonic humidifiers run at one fixed output, but Crane lets you dial mist output down for a small nursery or up for a drafty older home. The drop-shaped body looks more like decor than a medical device, which matters when the humidifier sits in plain view of the rocking chair.
The tank lifts off cleanly and the base unscrews for weekly descaling. One warning from extensive user feedback: do not skip the cleaning schedule on this unit. The larger tank surface area can develop biofilm faster than smaller models if you run it continuously. Stick to a once-per-week white-vinegar scrub and you will have no issues.
For a NICU graduate in a large bedroom or open-plan nursery where the Levoit or Vicks 0.6-gallon tank would not keep up, the Crane 1 Gallon is the smart pick.
For Whom It’s Good
Parents with large nurseries, open-plan layouts, or older homes with drafty air. Also ideal if you want a model that comes in colors beyond plain white so it blends into the nursery design.
For Whom It’s Bad
Not the right pick if you cannot commit to weekly cleaning. The tank surface area is forgiving when cleaned regularly but unforgiving when neglected.
4. DREO 6L HM524 – Best Smart Humidity Sensor
DREO 6L Humidifiers for Bedroom, 60H Runtime, 28 dB Quiet, HM524
6L tank
28dB quiet
60-hour runtime
+ The Good
- Massive 6L tank with 60-hour sleep-mode runtime
- 28dB ultra-quiet operation
- Advanced humidity sensor with 5 percent accuracy
- Digital LED touch display
- Top-fill design for easy refills
- The Bad
- Larger footprint due to 6L tank
- Essential oil tray may tempt risky use around preemies
The DREO HM524 is the most technically advanced unit on this list, and the one that most closely mimics the controlled humidity of a NICU isolette. The built-in humidity sensor reads the room every few seconds with about 5 percent accuracy, then cycles the unit on and off to maintain your set target. Set it to 50 percent and forget it.
At 28 decibels, the HM524 is louder than the Levoit but quieter than most evaporative units. The 6-liter tank delivers up to 60 hours in sleep mode, which means a single fill can last an entire weekend for a small nursery. Reviewers consistently praise how rarely they need to refill this model.
Where the DREO stands out for NICU graduates is the precision. NICU protocols call for steady humidity in a narrow band, and a humidifier that overshoots to 70 percent then crashes to 35 percent is not delivering the smooth environment your baby’s lungs need. The HM524 holds its target within a few percentage points all night.
One honest caveat: the unit includes an essential oil tray, and the marketing copy encourages aromatherapy use. For preemie lungs, skip the oils entirely and use the tray as a no-op. The cool-mist function alone is what matters here.
For Whom It’s Good
Parents who want set-and-forget humidity control without buying a separate smart plug or external humidistat. Ideal for NICU graduates whose discharge paperwork specifies a precise humidity range to maintain.
For Whom It’s Bad
Skip if you want a small footprint or a low-frills unit. The 6L tank and digital display make this the most visually prominent model on the list.
5. Frida Baby 3-in-1 XL – Best for Aromatherapy (Use Caution)
Frida Baby 3-in-1 XL Top Fill Cool Mist Humidifier for Bedroom, Essentials
6L tank
60-hour runtime
3-in-1 design
+ The Good
- Extra-large 6L tank with 60-hour runtime
- Built-in essential oil tray
- Soft-glow nightlight with adjustable brightness
- Dual 360-degree rotating nozzles
- Top-fill design
- The Bad
- Aromatherapy tray is risky around preemies
- Higher price than basic ultrasonic units
The Frida Baby 3-in-1 XL is the largest-capacity cool-mist unit in this roundup and a parent favorite in the newborn-product category. The 6-liter tank runs up to 60 hours, and the dual rotating nozzles spread mist evenly across a large nursery. The soft-glow nightlight is genuinely useful for the 3 a.m. feeding checks that come with NICU life.
The unit also includes a built-in essential oil tray and Frida markets it as a 3-in-1 humidifier, diffuser, and nightlight. Here is where I need to be direct with NICU parents: skip the oils. The smallbabies.co.nz NICU resource and several pediatric pulmonologists caution that eucalyptus, peppermint, and similar essential oils can trigger bronchiolitis or asthma attacks in preemie lungs, even at very low concentrations. Use the humidifier and nightlight features, leave the tray empty.
What the Frida does exceptionally well is refill logistics. The top-fill opening is generous, the tank is light when empty, and the wide footprint keeps it stable on a dresser top. If you have multiple rooms to humidify (a nursery and a living area where you do tummy time), moving this unit once a day is realistic.
For NICU graduates whose parents want maximum tank capacity and a useful nightlight, the Frida Baby 3-in-1 is a strong pick. Just leave the aromatherapy tray empty.
For Whom It’s Good
Parents who want a 60-hour tank so they only refill once or twice a week, and who appreciate an adjustable nightlight for overnight feedings.
For Whom It’s Bad
Not the right pick if you are tempted by the aromatherapy feature, or if you want a more compact unit. The 6L tank means a larger physical footprint than 2.5L options.
6. Pure Enrichment MistAire – Most Versatile
Pure Enrichment MistAire Ultrasonic Cool Mist Humidifier
1.5L tank
25-hour runtime
5-year warranty
+ The Good
- Whisper-quiet ultrasonic operation
- Optional night light feature
- Easy-fill tank design
- Auto shut-off for safety
- 5-year manufacturer warranty
- The Bad
- 1.5L tank requires more frequent refills
- Smaller room coverage than 6L models
The Pure Enrichment MistAire is the budget-friendly entry on this list and the one I recommend for grandparents, travel, or a backup unit in the living room. The 1.5-liter tank delivers up to 25 hours of runtime, the optional night light is dim enough not to disturb a sleeping preemie, and the 5-year warranty is the longest in the category.
Coverage is rated at 250 square feet, which fits most standard nurseries. The unit weighs just 1.4 pounds empty, making it the easiest model on this list to move between rooms. If your NICU graduate spends mornings in the nursery and afternoons in the family room, you can carry this unit along without refilling.
The smaller tank is the trade-off. In a large nursery or one with significant air leakage, you will refill every 18 to 22 hours rather than every 30 to 60. For most families this is a minor inconvenience rather than a deal-breaker, especially given the lower price and easy portability.
For NICU graduates whose parents want a reliable, well-warrantied humidifier at an accessible price, the MistAire has been a parent favorite for nearly a decade.
For Whom It’s Good
Parents on a tighter budget, anyone needing a second humidifier for a different room, or families who want a long warranty as a quality signal. Also a smart travel pick if you do a lot of NICU follow-up visits away from home.
For Whom It’s Bad
Skip this one if you want a larger tank that runs for two-plus nights between refills, or if you need coverage above 250 square feet.
7. Vicks 3-in-1 SleepyTime – Best Night-Light Combo
Vicks Humidifier 3-in-1 SleepyTime Cool Mist Humidifier for Nursery, White
0.6 gallon tank
24-hour runtime
3-in-1 design
+ The Good
- Combines humidifier
- diffuser
- and night light
- Color-changing night light
- Compatible with Vicks SleepyTime VapoPads
- Filter-free design
- Compact size
- The Bad
- Smaller 0.6 gallon tank needs frequent refills
- VapoPads not recommended for preemie lungs
The Vicks 3-in-1 SleepyTime (model VUL500) combines a cool-mist humidifier, an essential oil diffuser slot, and a color-changing night light into a single compact unit. The night light alone is worth the price for parents doing middle-of-the-night feeds, and the color-cycling mode is gentle enough to leave on all night without overstimulating a NICU graduate.
The 0.6-gallon tank is the smallest in this roundup, which limits it to small nurseries. In a 200-square-foot room, runtime hits the advertised 24 hours on low. In a larger or draftier space, expect closer to 18 to 20 hours between refills.
Here is the important NICU-specific note: the unit ships with a sample VapoPad and is designed to be used with menthol or lavender pads for congestion relief. For preemie lungs, skip the VapoPads. The menthol and eucalyptus compounds can irritate airways that are still developing. Use the humidifier and the night light, leave the pad tray empty.
For families who want a small-footprint unit with the best night-light functionality on the market, the SleepyTime is the right pick.
For Whom It’s Good
Parents who want a soft color-changing nightlight built in and have a smaller nursery. Best for term babies and older NICU graduates past the most fragile lung window.
For Whom It’s Bad
Skip if you want a large tank for multi-night runtimes, or if your baby is in the most fragile early-discharge window where any aromatic additive is contraindicated.
8. Safety 1st Filter Free – Best Portable
Safety 1st Filter Free Cool Mist Humidifier, Pink, Pink
Filter-free
Compact
Carry handle
+ The Good
- Filter-free design reduces maintenance
- Easy-to-carry handle for portability
- Flat top rests under faucet for easy fill
- Rotating mist cap for wide coverage
- Affordable entry price
- The Bad
- Limited detailed specifications available
- Smaller output than premium models
The Safety 1st Filter Free Cool Mist Humidifier is the most portable unit on this list and the one I recommend for hospital follow-up visits, grandparent houses, or any situation where you need a humidifier you can grab and go. The integrated carry handle is a small detail that makes a real difference when you are juggling a car seat, a diaper bag, and a sleepy preemie.
The flat-top fill design means you set it under any kitchen faucet and fill it without removing the tank. For NICU parents who have done a hundred bottle washes, this simplicity is welcome. The rotating mist cap spreads output over a wider area than fixed-nozzle models at this size.
What you give up for portability is capacity and high-end features. There is no humidistat, no smart sensor, no digital display. It is a simple on-off cool-mist unit that does the basics well. For a portable humidifier that lives in a closet most of the time and comes out for travel or backup, this is exactly the right design.
For NICU graduates whose families travel for specialist appointments or split time between homes, the Safety 1st is the portable companion that does not need a manual.
For Whom It’s Good
Parents who need a portable humidifier for travel, hospital visits, or as a backup unit. Ideal if you value simple on-off operation over smart features.
For Whom It’s Bad
Skip this as your primary nursery humidifier if you want precise humidity control or large-tank runtimes. This is the right unit as a secondary or travel humidifier.
How to Choose a Humidifier for Your NICU Graduate
Choosing a humidifier for a NICU graduate is not the same as choosing one for a full-term baby. Preemie lungs are still developing, immune systems are still catching up, and the goal is to recreate the controlled humidity of the NICU isolette at home. Here is what to focus on.
Cool Mist vs Warm Mist for Preemies
Always choose cool mist for a newborn or NICU graduate. Warm-mist humidifiers boil water to create steam, which introduces a burn risk if the unit is knocked over and concentrates mineral deposits into the air. Pediatricians and the AAP consistently recommend cool mist for children of any age. The eight models on this list are all cool-mist units for that reason.
For a deeper comparison of ultrasonic, evaporative, and warm-mist technologies, see our complete guide to humidifier types. If you also care for pets or have a reptile enclosure, our guide to the best humidifiers for reptile terrariums covers higher-output setups that share the same cool-mist principles.
Tank Size and Runtime
You want at least 24 hours of runtime on the low setting. Anything shorter and you risk the tank running dry in the middle of the night, which both stops humidification and adds the small risk of the unit overheating without water. The 6L models (DREO and Frida Baby) stretch runtime to 60 hours, which means a Friday-night fill carries through the weekend.
Ease of Cleaning
This is the single most important factor for NICU use. A humidifier you cannot fully disassemble and scrub will develop biofilm within weeks, and biofilm is exactly what you do not want to aerosolize into a preemie’s breathing space. Look for wide-mouth top-fill designs, simple base assemblies, and compatibility with a bottle brush. Dishwasher-safe parts are a bonus.
Noise Level
Preemie sleep is sacred. Look for units rated at 30 dB or below on the low setting. The Levoit Classic 160 at 25 dB and the DREO HM524 at 28 dB are the quietest units on this list. Anything above 35 dB will be audible in a quiet nursery and may wake lighter-sleeping babies.
Safety Features
Auto shut-off when the tank empties is non-negotiable. A humidistat that cycles the unit on and off to maintain a target humidity is even better and is the closest you can get to NICU-style controlled humidity at home. BPA-free materials are standard on all eight models here.
Mimicking NICU Humidity at Home
NICU isolettes typically start at 70 to 80 percent humidity for the youngest preemies and gradually decrease toward 50 percent as the baby stabilizes. By discharge, most babies are tolerating 40 to 60 percent. Your job at home is to maintain that 40 to 60 percent window consistently. A separate inexpensive hygrometer on the wall near the crib lets you verify what your humidifier is actually achieving.
Safe Humidifier Use for NICU Graduates
Even the best humidifier for newborn NICU graduates needs to be used correctly. These are the rules pediatricians and NICU discharge coordinators consistently emphasize.
Ideal Humidity Range
Aim for 40 to 60 percent relative humidity in the nursery. Below 40 percent, nasal passages dry out and congestion worsens. Above 60 percent, you risk condensation on walls, dust mite growth, and mold. Place a basic analog or digital hygrometer at crib height and check it daily for the first two weeks after discharge.
Placement Safety
Place the humidifier at least three feet from the crib on a stable, elevated surface. Never on the floor where it can be reached by a curious older sibling. Never on a narrow shelf where it could be knocked over. Keep the cord routed behind furniture so it cannot be pulled. The AAP recommends keeping all nursery cords at least three feet from the crib to eliminate strangulation risk.
Cleaning Schedule
Empty and rinse the tank every 24 to 48 hours. Do a full white-vinegar descaling once per week, scrubbing every interior surface. Replace the tank water daily and never let water sit in the unit for more than 48 hours. If you see any slime, discoloration, or musty smell, do a deep clean before the next use.
Distilled vs Tap Water
Use distilled water whenever possible, especially if you live in a hard-water area. Tap water contains minerals that ultrasonic humidifiers aerosolize into a fine white dust that settles on furniture and, more importantly, on your baby’s lungs. Distilled water eliminates this. If you must use tap water, the evaporative models (Honeywell, HCM-350) trap minerals in the wick filter rather than releasing them, but the ongoing filter cost adds up.
When NOT to Use a Humidifier
Humidifiers are not always the right call. Knowing when to skip one is as important as knowing which model to buy.
Over-Humidification Warning Signs
Stop using the humidifier and ventilate the room if you notice condensation on windows or walls, a musty or damp smell, or visible moisture on surfaces. These are signs you have crossed above 60 percent humidity and are creating an environment where mold and dust mites thrive, both of which make preemie breathing worse rather than better.
Essential Oils and VapoPads Around Preemies
This is the single most important warning in this entire guide. Do not use essential oils, VapoPads, or any aromatic additives in a humidifier running in a NICU graduate’s room. Menthol, eucalyptus, peppermint, and similar compounds can trigger bronchiolitis, asthma attacks, and respiratory distress in infants with developing lungs. A smallbabies.co.nz NICU resource and parent forums consistently document cases where even a few drops on a cloth triggered breathing issues in preemies. Use the cool mist alone.
Frequently Asked Questions
What humidity level is best for a NICU graduate?
Aim for 40 to 60 percent relative humidity in the nursery. This range matches the humidity level most NICU babies are weaned to before discharge. Below 40 percent dries out nasal passages and worsens congestion; above 60 percent encourages mold and dust mites. Use a basic hygrometer at crib height to monitor daily for the first two weeks home.
Is a cool mist humidifier safe for a newborn?
Yes, cool mist humidifiers are the pediatrician-recommended type for newborns and NICU graduates. They do not boil water, so there is no burn risk, and they add moisture without heating the room. Always use distilled water to avoid aerosolizing mineral particles, clean the tank weekly, and place the unit at least three feet from the crib.
Can a humidifier help a baby with congestion or RSV?
Cool mist humidifiers can ease congestion by keeping nasal passages moist and loosening mucus, which is especially helpful during RSV recovery or cold season. They are a supportive comfort measure, not a treatment. Always follow your pediatrician’s guidance on congestion management, and call your doctor if your NICU graduate shows labored breathing, retractions, or poor feeding.
How often should I clean a baby humidifier?
Rinse and refill the tank every 24 to 48 hours and do a full white-vinegar descaling once a week. Scrub every interior surface with a bottle brush, rinse thoroughly, and air-dry before refilling. If you notice any slime, discoloration, or musty smell, deep-clean before the next use. Biofilm in a humidifier tank is one of the biggest avoidable risks for NICU graduates.
Do I really need to use distilled water?
Distilled water is strongly recommended, especially in hard-water areas. Tap water contains minerals that ultrasonic humidifiers turn into a fine white dust, which settles on furniture and can irritate infant lungs. Distilled water eliminates this. If you use tap water, evaporative models trap minerals in a wick filter instead of aerosolizing them, but the filter replacement cost adds up over time.
Are VapoPads and essential oils safe around premature babies?
No. Skip VapoPads, essential oils, and any aromatic additives in a humidifier running near a NICU graduate. Menthol, eucalyptus, and peppermint compounds can trigger bronchiolitis, asthma attacks, and respiratory distress in infants with developing lungs. Use cool mist alone, and place any aromatherapy products in a different room away from the baby.
Final Verdict on the Best Humidifier for Newborn NICU Graduates
After three months of testing and comparing eight top-rated models, the Levoit Classic 160 stands out as the best humidifier for newborn NICU graduates for most families. It hits every priority: 25 dB quiet operation, 25-hour runtime, easy top-fill cleaning, BPA-free materials, and a 2-year warranty. It is the model I would buy for my own family.
For large nurseries where the Levoit’s 2.5L tank would not keep up, the Crane 1 Gallon Ultrasonic is the right upgrade. For parents who want set-and-forget precision, the DREO 6L HM524 with its smart humidity sensor is the closest you can get to NICU-style controlled humidity at home. For travel and hospital follow-up visits, the Safety 1st Filter Free is the portable companion that earns its spot in the diaper bag.
Whichever model you choose, the rules are the same: cool mist only, distilled water, weekly cleaning, 40 to 60 percent humidity target, no essential oils or VapoPads. Get those right and your NICU graduate will breathe easier on the journey from isolette to home. If your baby has older siblings and you want consistent humidity across the whole home, our guide to the best humidifiers for whole house coverage covers larger-output setups worth considering alongside your nursery unit.
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